HTTP/2 (TLS) ProxyPass "/app" "h2://app.example.com" ProxyPassReverse "/app" "https://app.example.com"
HTTP/2 (cleartext) ProxyPass "/app" "h2c://app.example.com" ProxyPassReverse "/app" "http://app.example.com"
References
https://httpd.apache.org/docs/2.4/mod/mod_proxy_http2.html